CJC 1295 w/ DAC (5mg)

Description CJC 1295 w/ DAC is a synthetically modified tetrasubstituted research reagent derived from the endogenous 29-amino-acid sequence of Growth Hormone-Releasing Hormone (GHRH). It is chemically distinct from short-acting GHRH analogues due to the addition of a C-terminal maleimidopropionamide moiety, known as a Drug Affinity Complex (DAC). This modification is designed to resist enzymatic degradation by dipeptidyl peptidase-4 (DPP-4) and covalently bond to endogenous serum albumin, significantly enhancing its circulatory half-life. Researchers utilize this molecule to investigate the sustained activation of the anterior pituitary, the metabolic consequences of chronically elevated basal growth hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) levels, and the preservation of natural neuroendocrine pulsatility under continuous receptor stimulation. Biochemical Characteristics Sequence/Structure: Peptide; Tetrasubstituted GHRH(1-29) analogue covalently linked via the C-terminus to a maleimidopropionyl Drug Affinity Complex (DAC). Receptor Affinity: Binds specifically and with high affinity to the growth hormone-releasing hormone receptor (GHRHR) on pituitary somatotrophs, facilitating robust neuroendocrine interactions. Stability: Supplied as a lyophilized salt to ensure long-term stability. The DAC modification facilitates albumin conjugation in vivo, resisting rapid proteolytic cleavage and drastically increasing its half-life to approximately 6 to 8 days compared to unmodified peptides. Specificity: Highly specific stimulator of anterior pituitary somatotrophs, acting primarily to promote steady-state growth hormone secretion and secondary hepatic IGF-1 expression. Chemical Properties Property Specification Molecule Name CJC 1295 w/ DAC Synonyms DAC-GRF; CJC-1295; Tetrasubstituted GRF (1-29) with DAC Molecular Formula $C_{152}H_{252}N_{44}O_{42}$ Molecular Weight $3367.97~g/mol$ Form Lyophilized Powder Purity 99% (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA and SDS available per lot