DSIP (Delta Sleep-Inducing Peptide) (5mg)
$ 45.00
Description Delta Sleep-Inducing Peptide (DSIP) is an amphiphilic, 9-amino-acid regulatory neuropeptide first isolated in 1977 from the cerebral venous blood of rabbits following induced slow-wave sleep. While its initial characterization focused heavily on its ability to induce delta rhythm electroencephalogram (EEG) activity and promote sleep, subsequent research has revealed that DSIP functions as a highly pleiotropic neuromodulator. Researchers utilize this molecule to investigate its broad systemic effects, which include the modulation of the hypothalamic-pituitary-adrenal (HPA) axis, the stimulation of specific gonadotropins, and the attenuation of stress-induced metabolic disturbances. Due to its ability to readily cross the blood-brain barrier, DSIP is heavily employed in neurobiological assays examining oxidative phosphorylation, hypoxia-induced neurotoxicity, and the buffering of central nervous system stress responses. Biochemical Characteristics Sequence/Structure: Nonapeptide (9 amino acids); Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). Permeability: Exhibits amphiphilic properties that allow it to successfully cross the blood-brain barrier (BBB) without requiring a carrier molecule, facilitating direct central nervous system interaction. Stability: Supplied as a lyophilized salt to ensure long-term stability. In physiological models, endogenous DSIP possesses a relatively short half-life and often complexes with carrier proteins; synthetic administration allows for rapid, acute receptor engagement. Specificity: Acts as a broad neuromodulator, specifically altering the release of corticotropin, luteinizing hormone, and somatoliberin, while directly influencing mitochondrial bioenergetics. Chemical Properties Property Specification Molecule Name DSIP (Delta Sleep-Inducing Peptide) Synonyms Emideltide Molecular Formula C35H48N10O15 Molecular Weight 848.81 g/mol Form Lyophilized Powder Purity ≥99% (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA and SDS available per lot
