Hexarelin / CJC 1295 no DAC Blend (5mg/5mg)

Description The Hexarelin / CJC 1295 no DAC Blend is a specialized research reagent containing two distinct, synergistic synthetic peptides designed to investigate advanced neuroendocrine and cardiovascular pathways. Hexarelin is a highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR-1a) and uniquely possesses a high binding affinity for the non-GHSR CD36 scavenger receptor, allowing it to mediate profound GH-independent cardioprotective and lipolytic effects. CJC 1295 no DAC (Modified GRF 1-29) is a 29-amino-acid analogue of endogenous GHRH engineered with four specific amino acid substitutions to resist rapid dipeptidyl peptidase-4 (DPP-4) enzymatic cleavage. Because it lacks a Drug Affinity Complex (DAC), it possesses a half-life of approximately 30 minutes—ideal for mimicking brief, physiological GH pulsatility without inducing receptor desensitization. In experimental pharmacology, the concurrent administration of a GHSR-1a agonist (Hexarelin) and a GHRH analogue (CJC 1295 no DAC) produces a highly synergistic, rather than additive, amplification of growth hormone (GH) secretion. This blend acts as a robust chemical probe for studying the bypass of somatostatin-mediated negative feedback alongside localized tissue repair mechanisms. Biochemical Characteristics Chemically, this blend provides a dual-receptor targeting approach for in vitro and in vivo metabolic and cardiovascular assays. Sequence/Structure: A proprietary blend of two stabilized synthetic peptides. Hexarelin (6 amino acids with D-amino substitutions) and CJC 1295 no DAC / Modified GRF 1-29 (29 amino acids, tetrasubstituted). Receptor Affinity: Simultaneously targets the GHRH receptor (GHRHR) on pituitary somatotrophs, the Ghrelin receptor (GHSR-1a) in the hypothalamus/pituitary, and the CD36 scavenger receptor on cardiomyocytes and macrophages. Stability: Supplied as a co-lyophilized salt to prevent hydrolytic degradation and ensure the structural integrity of both peptide chains during long-term storage. Specificity: Designed to competitively stimulate both primary pathways of the somatotropic axis while simultaneously investigating CD36-dependent tissue repair without continuous, non-pulsatile receptor overload. Chemical Properties Property Specification Molecule Name Hexarelin / CJC 1295 no DAC Blend Synonyms Examorelin / Modified GRF (1-29) Blend Molecular Formula Hexarelin: C47H58N12O6 Molecular Weight Hexarelin: 887.05 g/mol Form Lyophilized Powder Purity ≥99% (Verified via HPLC) Solubility Soluble in water and organic solvents (refer to SDS) Documentation COA available per lot; SDS available