Metabolic Blend NAD / MOTS-c / 5-Amino-1MQ (100mg/10mg/10mg)
$ 90.00
Description The Metabolic Blend NAD / MOTS-c / 5-Amino-1MQ is a composite research reagent that integrates three distinct regulators of cellular metabolism. 5-Amino-1MQ is a membrane-permeable small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT), preventing the metabolic depletion of nicotinamide. MOTS-c is a 16-amino acid mitochondrial-derived peptide that functions as an exercise mimetic, translocating to the nucleus during stress to regulate energy homeostasis. NAD (Nicotinamide adenine dinucleotide) is a critical dinucleotide coenzyme involved in cellular redox reactions. Researchers utilize this complex blend to investigate the intersection of these pathways, specifically evaluating how simultaneously fueling the NAD salvage pathway and providing mitochondrial signaling peptides impacts metabolic flux, insulin resistance, and cellular longevity models. Biochemical Characteristics Sequence/Structure: Heterogeneous mixture of a dinucleotide coenzyme (NAD ), a 16-amino acid peptide (MOTS-c: MRWQEMGYIFYPRKLR), and a quinolinium small molecule (5-Amino-1MQ). Permeability: Components exhibit distinct interaction profiles; 5-Amino-1MQ readily permeates the cell membrane to access cytosolic NNMT, MOTS-c engages intracellular targets and translocates to the nucleus, and NAD influences both extracellular receptors and intracellular enzymatic pathways. Stability: Supplied as a co-lyophilized salt to ensure long-term stability and prevent hydrolytic degradation of the peptide and coenzyme structures during storage. Specificity: Designed to probe multiple metabolic targets simultaneously: NNMT inhibition (5-Amino-1MQ), AMPK activation and nuclear gene regulation (MOTS-c), and sirtuin/PARP substrate replenishment (NAD ). Chemical Properties Property Specification Molecule Name Metabolic Blend (NAD / MOTS-c / 5-Amino-1MQ) Synonyms Nadide / Mitochondrial open reading frame of the 12S rRNA-c / 5-amino-1-methylquinolinium PubChem CID 5892 (NAD ); 146675088 (MOTS-c); 950107 (5-Amino-1MQ) Molecular Formula Mixture (C21H27N7O14P2 / C101H152N28O22S2 / C10H11N2) Molecular Weight ~663.4 g/mol (NAD ) / 2174.6 g/mol (MOTS-c) / 159.2 g/mol (5-Amino-1MQ) Form Lyophilized Powder Purity 99% (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA and SDS available per lot
