N-Acetyl Semax Amidate (20mg)

Description N-Acetyl Semax Amidate is a synthetically modified heptapeptide research reagent derived from the endogenous adrenocorticotropic hormone fragment ACTH(4-10). It is chemically distinct from standard Semax due to the addition of an acetyl group at the N-terminus and an amide group at the C-terminus, modifications designed to resist enzymatic degradation and significantly enhance blood-brain barrier permeability. Researchers utilize this molecule to investigate the modulation of neurotrophic factors (such as BDNF), the protection of neuronal tissues during ischemic stroke models, and its broader systemic effects on the immune system under stress conditions. Biochemical Characteristics Sequence/Structure: Peptide (7 amino acids); Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2; N-acetyl and C-amide modified heptapeptide. Permeability: Demonstrates exceptional ability to cross the blood-brain barrier due to its modified, uncharged termini, facilitating robust central nervous system interactions. Stability: Supplied as a lyophilized salt to ensure long-term stability. The acetylation and amidation prevent rapid proteolytic cleavage by exopeptidases, drastically increasing its half-life compared to the unmodified peptide. Specificity: Highly specific modulator of central monoaminergic systems and neurotrophin expression, acting without the steroidal (cortisol-releasing) activity of full-length ACTH. Chemical Properties Property Specification Molecule Name N-Acetyl Semax Amidate Synonyms N-acetyl semax; Ac-MEHFPGP-NH2 PubChem CID 172638603 Molecular Formula C39H54N10O10S Molecular Weight 855.0 g/mol Form Lyophilized Powder Purity $ge99%$ (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA and SDS available per lot