CJC 1295 (No DAC) & Ipamorelin Blend (10mg)
$ 67.50
Description The CJC 1295 (No DAC) & Ipamorelin Blend is a dual-action research tool utilized to study the coordinated regulation of growth hormone (GH) secretion. CJC 1295 (No DAC): Also known as Modified GRF 1-29, this component is a synthetic modification of the endogenous GHRH (1-29) fragment. It lacks the Drug Affinity Complex (DAC), resulting in a pharmacokinetic profile that mimics the natural, pulsatile release of GHRH, unlike the prolonged action of its DAC-conjugated counterpart. Ipamorelin: A pentapeptide and selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). It is distinguished by its high specificity, stimulating GH release without significantly impacting cortisol or prolactin levels in experimental models. In laboratory settings, this blend is employed to maximize intracellular signaling for GH synthesis and release. The combination allows researchers to observe the “multiplier effect” where the concurrent activation of the GHRH receptor (by CJC 1295) and the GHS receptor (by Ipamorelin) results in a GH secretory pulse that exceeds the sum of individual administrations. Biochemical Characteristics This product combines two distinct peptide classes to target separate receptors on the pituitary somatotroph. Sequence/Structure: CJC 1295 (No DAC): A 29-amino acid peptide substituted at four positions to enhance resistance to cleavage by the enzyme DPP-IV. Ipamorelin: A short-chain pentapeptide (5 amino acids) containing the non-natural amino acids Aib (aminoisobutyric acid) and 2-Nal (2-naphthylalanine). Signaling Synergy: The blend is designed to investigate the coupling of the cAMP/PKA pathway (via GHRH receptor) and the PLC/IP3 pathway (via GHS receptor), providing a comprehensive model for pituitary activation. Selectivity: Ipamorelin is chosen for this blend due to its lack of cholinergic activity and minimal off-target effects on ACTH or cortisol pathways compared to other secretagogues. Chemical Properties Property Specification (CJC 1295 No DAC) Specification (Ipamorelin) Molecule Name Mod GRF 1-29; Tetrasubstituted GRF 1-29 Ipamorelin Sequence Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 Aib-His-D-2-Nal-D-Phe-Lys-NH2 CAS Number 863288-34-0 170851-70-4 Molecular Formula C152H252N44O42 C38H49N9O5 Molecular Weight 3367.9 g/mol 711.85 g/mol Purity ≥99% (Verified via HPLC) ≥99% (Verified via HPLC) Form Lyophilized Powder (Blend) Lyophilized Powder (Blend)
