HGH Frag 176-191 (6mg)
$ 90.00
Description HGH Fragment 176-191 is a synthetic, truncated polypeptide derived from the discrete lipolytic domain of human growth hormone. While full-length hGH binds to the classical growth hormone receptor to stimulate systemic growth, cellular proliferation, and insulin-like growth factor-1 (IGF-1) production, the 176-191 fragment specifically isolates the hormone’s lipid-mobilizing properties. In experimental pharmacology, researchers utilize this molecule to investigate targeted fat oxidation and lipolysis in adipocytes. Because it lacks the N-terminal sequences of the intact hormone, HGH Fragment 176-191 provides a precise chemical probe to study metabolic energy expenditure and adipose tissue reduction without inducing the diabetogenic (insulin resistance) or hyperplastic side effects typically associated with intact hGH administration. Biochemical Characteristics Chemically, HGH Fragment 176-191 is engineered to mimic the structural conformation of the intact hormone’s C-terminus, relying on a stabilized sequence to interact with peripheral metabolic pathways. Sequence/Structure: 16-amino acid polypeptide; Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe. Receptor Affinity: Demonstrates targeted activity within adipose tissue, modulating beta-3-adrenergic receptor (β3-AR) RNA expression, though its lipolytic actions are complex and not exclusively mediated by direct receptor agonism. It does not bind to the classical hGH receptor. Stability: Supplied as a lyophilized salt. The structure includes an internal disulfide bond between cysteine residues for molecular stability and resistance to rapid proteolytic degradation. Specificity: Highly specific for lipolytic and antilipogenic pathways; completely lacks the IGF-1-mediated growth-promoting and insulin-antagonistic properties of the full 191-amino acid parent hormone. Chemical Properties Property Specification Molecule Name HGH Fragment 176-191 Synonyms Somatotropin (176-191); GH Lipolytic Fragment; AOD9604 analogue PubChem CID 71300630 Molecular Formula C78H123N23O23S2 Molecular Weight 1815.10 g/mol Form Lyophilized Powder Purity ≥99% (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA available per lot; SDS available
