N-Acetyl Selank Amidate (20mg)

Description N-Acetyl Selank Amidate is a synthetically modified heptapeptide research reagent derived from the endogenous immunomodulatory tetrapeptide tuftsin. It is chemically distinct from standard Selank due to the addition of an acetyl group at the N-terminus and an amide group at the C-terminus, modifications designed to resist enzymatic degradation and significantly enhance blood-brain barrier permeability. Researchers utilize this molecule to investigate the modulation of neurotrophic factors (such as BDNF), the mitigation of stress-induced morphological damage in peripheral tissues, and its broad anxiolytic and immunomodulatory effects in behavioral and physiological models. Biochemical Characteristics Sequence/Structure: Peptide (7 amino acids); Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2; N-acetyl and C-amide modified heptapeptide analogue of tuftsin. Permeability: Demonstrates exceptional ability to cross the blood-brain barrier due to its modified, uncharged termini, facilitating robust central nervous system interactions. Stability: Supplied as a lyophilized salt to ensure long-term stability. The terminal acetylation and amidation prevent rapid proteolytic cleavage by exopeptidases, drastically increasing its half-life compared to the unmodified peptide. Specificity: Highly specific modulator of central neurotrophin expression and cytokine/chemokine receptor signaling, acting primarily as an anxiolytic and systemic stress-buffer. Chemical Properties Property Specification Molecule Name N-Acetyl Selank Amidate Synonyms NA-Selank Amidate; Ac-TKPRPGP-NH2 PubChem CID N/A Molecular Formula C35H60N12O9 Molecular Weight 792.9 g/mol Form Lyophilized Powder Purity $ge99%$ (Verified via HPLC) Solubility Soluble in water and aqueous buffers (refer to SDS) Documentation COA and SDS available per lot